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Invitrogen

NUDT4 Polyclonal Antibody

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NUDT4 Polyclonal Antibody

Product Details

PA5-53612

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NUDT4. Recombinant protein control fragment (Product #RP-91860).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2644876

Product Specific Information

Immunogen sequence: KVLQCHKPVH AEYLEKLKLG CSPANGNSTV PSLPDNNALF VTAAQTSGLP SSVR

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.

Target Information

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydolase type II; Diphosphoinositol polyphosphate phosphohydrolase 2; Diphosphoinositol polyphosphate phosphohydrolase NUDT4B; diphosphoinositol polyphosphate phosphohydrolase type 2; DIPP-2; DIPP-2B; DIPP2 alpha; DIPP2 beta; KIAA0487; Nucleoside diphosphate-linked moiety X motif 4; Nucleoside diphosphate-linked moiety X motif 4B; nudix (nucleoside diphosphate linked moiety X)-type motif 4; Nudix hydrolase 4B; Nudix motif 4; Nudix motif 4B; nudix-type motif 4; rDIPP2; unnamed protein product

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Gene Aliases: 4933436C10Rik; DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta; DRCF-5; HDCMB47P; KIAA0487; NUDT4; NUDT4B

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UniProt ID: (Human) Q9NZJ9, (Mouse) Q8R2U6, (Rat) Q99MY2

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Entrez Gene ID: (Human) 11163, (Mouse) 71207, (Rat) 94267

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Function(s)
endopolyphosphatase activity RNA binding protein binding diphosphoinositol-polyphosphate diphosphatase activity pyrophosphatase activity hydrolase activity snoRNA binding bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity metal ion binding inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity thiamine-pyrophosphatase activity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity UDP-2,3-diacylglucosamine hydrolase activity bis(5'-nucleosyl)-tetraphosphatase activity dATP pyrophosphohydrolase activity dihydroneopterin monophosphate phosphatase activity dihydroneopterin triphosphate pyrophosphohydrolase activity dITP diphosphatase activity dTTP diphosphatase activity XTP diphosphatase activity ATP-dependent 5'-3' DNA helicase activity phosphocholine hydrolase activity m7G(5')pppN diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity phosphatase
Process(es)
calcium-mediated signaling intracellular signal transduction diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process phosphatidylinositol metabolic process
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