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Invitrogen
SCNN1D Polyclonal Antibody
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Product Details
PA5-55451
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCNN1D. Recombinant protein control fragment (Product #RP-90378).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELLDEFAREN IDSLYNVNLS KGRAALSATV PRHEPPFHLD REIRLQRLSH SGSRVRVGFR LCNSTGGDCF YRGYTSGVAA VQDWYHFHYV DILALLPAAW EDSHGSQDGH FVLSCSYDGL DCQARQFRTF HHPTYGSCYT VDG
Highest antigen sequence identity to the following orthologs: Mouse - 26%, Rat - 25%.
Target Information
SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amiloride-sensitive sodium channel subunit delta; Delta-ENaC; Delta-NaCH; epithelial Na(+) channel subunit delta; Epithelial sodium channel subunit delta; ion channel; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; sodium channel epithelial 1 delta subunit; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, voltage-gated, type I, delta polypeptide; unnamed protein product
Gene Aliases: DNACH; ENaCd; ENaCdelta; SCNED; SCNN1D
UniProt ID: (Human) P51172
Entrez Gene ID: (Human) 6339
ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of blood pressure
ion transmembrane transport
sodium ion transmembrane transport
sensory perception of salty taste
sensory perception of sour taste
cellular response to acidic pH
sodium ion import across plasma membrane
cellular response to aldosterone
cellular response to vasopressin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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