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Invitrogen
ARAP1 Polyclonal Antibody
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Product Details
PA5-67101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human ARAP1. Recombinant protein control fragment (Product #RP-105502).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLPSTIAAPHP MDGPPGGSTP VTPVIKAGWL DKNPPQGSYI YQKRWVRLDT DHLRYFDSNK DAYSKRFISV ACISHVAAIG DQKFEVITNN RTFAFRAESD VERK
Highest antigen sequence identity to the following orthologs - mouse 80%, rat 82%.
Target Information
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; Centaurin-delta-2; Cnt-d2; KIAA0782
Gene Aliases: ARAP1; CENTD2; cnt-d2; KIAA0782
UniProt ID: (Human) Q96P48
Entrez Gene ID: (Human) 116985
positive regulation of receptor recycling
regulation of receptor internalization
actin filament organization
signal transduction
regulation of cell shape
regulation of endocytosis
regulation of cell projection organization
regulation of actin cytoskeleton organization
positive regulation of GTPase activity
regulation of bone resorption
photoreceptor cell maintenance
positive regulation of phagocytosis
regulation of small GTPase mediated signal transduction
positive regulation of cellular component organization
positive regulation of filopodium assembly
negative regulation of stress fiber assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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