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Invitrogen
Nkx2.2 Polyclonal Antibody
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Product Details
PA5-72761
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NKX2-2 antibody for a 19 amino acid synthetic peptide near the center of human NKX2-2. The immunogen is within amino acids 90 - 140 of NKX2-2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Drosophila NK2 transcription factor related, locus 2; glycoprotein GP330, renal; Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; homeobox protein Nkx2-2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; Nkx2.2
Gene Aliases: Nkx-2.2; NKX2-2; NKX2.2; NKX2B; tinman
UniProt ID: (Human) O95096, (Mouse) P42586
Entrez Gene ID: (Human) 4821, (Rat) 366214, (Mouse) 18088
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter proximal region DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
molecular_function
chromatin binding
transcription coactivator activity
transcription factor binding
homeodomain transcription factor
type B pancreatic cell differentiation
type B pancreatic cell development
pancreatic A cell fate commitment
type B pancreatic cell fate commitment
pancreatic PP cell fate commitment
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
nervous system development
brain development
response to glucose
positive regulation of gene expression
oligodendrocyte development
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell differentiation
spinal cord oligodendrocyte cell fate specification
optic nerve development
central nervous system neuron differentiation
cell differentiation
neuron differentiation
positive regulation of epithelial cell differentiation
endocrine pancreas development
response to progesterone
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
digestive tract development
neuron fate specification
astrocyte differentiation
oligodendrocyte differentiation
positive regulation of oligodendrocyte differentiation
ventral spinal cord interneuron fate determination
neuroendocrine cell differentiation
transcription from RNA polymerase II promoter
response to organic cyclic compound
regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
transcription, DNA-templated
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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