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Invitrogen
ATF3 Polyclonal Antibody
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Product Details
PA5-72945
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mammal,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a region of human ATF3 (within residues 100-150).
Conjugate
Form
Liquid
Concentration
1.27 mg/mL
Amount
127 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with most mammalian species based on sequence homology.
Target Information
ATF3 (Activating transcription factor 3) is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. It encodes a protein with a calculated molecular mass of 22 kD. ATF3 represses rather than activates transcription from promoters with ATF binding elements. An alternatively spliced form of ATF3 (ATF3 delta Zip) encodes a truncated form ATF3 protein lacking the leucine zipper protein-dimerization motif and does not bind to DNA. In contrast to ATF3, ATF3 delta Zip stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating transcription factor 3; ATF 3; ATF3; ATF3deltaZip2c; ATF3deltaZip3; cAMP-dependent transcription factor ATF-3; Cyclic AMP-dependent transcription factor ATF-3; Liver regeneration factor 1; LRF-1; Transcription factor LRG-21; unnamed protein product
Gene Aliases: ATF3; LRF-1; Lrf1; LRFI; LRG-21
UniProt ID: (Human) P18847, (Mouse) Q60765, (Rat) P29596
Entrez Gene ID: (Human) 467, (Mouse) 11910, (Rat) 25389
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
sequence-specific DNA binding
transcription regulatory region DNA binding
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
gluconeogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
positive regulation of gene expression
endoplasmic reticulum unfolded protein response
cellular response to amino acid starvation
response to endoplasmic reticulum stress
skeletal muscle cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of ERK1 and ERK2 cascade
positive regulation of TRAIL-activated apoptotic signaling pathway
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
cell fate determination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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