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Invitrogen
PKP2 Polyclonal Antibody
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FIGURE: 1 / 1
PKP2 Antibody (PA5-75421) in WB
Western blot analysis of PKP2 in Lane 1: SGC7901 whole cell lysate (20 µg), Lane 2: HCT116 whole cell lysate (20 µg), Lane 3: the Heart tissue lysate of rat (20 µg). Samples were incubated with PKP2 polyclonal antibody (Product # PA5-75421) at a dilution of 1:500.
Product Details
PA5-75421
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 634-680 of Human PKP2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: desmosomal protein; K112N; desmosomal protein; Q62DfsX22; desmosomal protein; T816RfsX9; desmosomal protein; V587I; Plakophilin-2; unnamed protein product
Gene Aliases: ARVD9; PKP2
UniProt ID: (Human) Q99959, (Rat) F1M7L9
Entrez Gene ID: (Human) 5318, (Rat) 287925
DNA binding
protein kinase C binding
protein binding
sodium channel regulator activity
intermediate filament binding
ion channel binding
alpha-catenin binding
cadherin binding
binding, bridging
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
protein complex scaffold
intermediate filament binding protein
desmosome assembly
desmosome organization
cell adhesion
cell-cell signaling
heart development
positive regulation of sodium ion transport
regulation of cell-substrate adhesion
intermediate filament bundle assembly
maintenance of organ identity
ventricular cardiac muscle tissue morphogenesis
protein localization to plasma membrane
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
cell-cell adhesion
regulation of ventricular cardiac muscle cell action potential
maintenance of protein localization at cell tip
regulation of substrate adhesion-dependent cell spreading
negative regulation of cell proliferation
gap junction assembly
single organismal cell-cell adhesion
negative regulation of cell migration
adherens junction maintenance
lipid homeostasis
cardiac muscle cell action potential
cell-cell signaling involved in cardiac conduction
bundle of His cell to Purkinje myocyte communication
regulation of bicellular tight junction assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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