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Invitrogen
CYB561D2 Polyclonal Antibody
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FIGURE: 1 / 1
CYB561D2 Antibody (PA5-75426) in WB
Western blot analysis of CYB561D2 in Lane 1: A549 whole cell lysate (40 µg), Lane 2: DLD whole cell lysate (40 µg), Lane 3: the Spleen tissue lysate of mouse (40 µg), Lane 4: the Spleen tissue lysate of rat (40 µg). Samples were incubated with CYB561D2 polyclonal antibody (Product # PA5-75426) at a dilution of 1:500.
Product Details
PA5-75426
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 61-110 of Human CYB561D2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein that contains six membrane spanning domains. Localized to endosomes and endoplasmic reticulum of the perinuclear region, CYB561D2 contains 2 heme-binding sites, through which it reduces ferric ions. CYB561D2 is ubiquitously expressed, with highest levels in lung, liver and kidney. Though expression of CYB561D2 is abundant in normal lung bronchial epithileal cells, CYB561D2 is absent in most lung cancers. The gene encoding CYB561D2 maps to human chromosome 3p21.3, a region that is prone to genetic alterations and is associated with frequent and early allele loss in many human cancers. Exogenous expression of CYB561D2 leads to the induction of caspase-independent apoptotic and autophagic pathways, resulting in the synergistic killing of tumor cells. This suggests an important role for CYB561D2 as a therapeutic intervention in cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 101F6 protein; cytochrome b-561 domain containing 2; Cytochrome b561 domain-containing protein 2; gene for 101F6 protein; OTTHUMP0000021067; OTTHUMP00000210675; OTTHUMP00000210676; Putative tumor suppressor protein 101F6; transmembrane ascorbate ferrireductase; Transmembrane reductase CYB561D2; tumor suppressor cytochrome b561; tumor suppressor, region 10; unnamed protein product
Gene Aliases: 101F6; AW049681; CYB561D2; LUCA12.2; TSCytb; TSP10; XXcos-LUCA11.4
UniProt ID: (Human) O14569, (Rat) Q641Y1, (Mouse) Q9WUE3
Entrez Gene ID: (Human) 11068, (Rat) 363137, (Mouse) 56368
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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