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Invitrogen
TRAF4 Polyclonal Antibody
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Product Details
PA5-77113
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human TRAF4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cysteine-rich domain associated with ring and TRAF domain; Cysteine-rich domain associated with RING and Traf domains protein 1; Cysteine-rich motif associated to RING and Traf domains protein 1; malignant 62; Metastatic lymph node gene 62 protein; MLN 62; putative TRAF4 splice-variant; TRAF4A; RING finger protein 83; RNF83malignant 62; TNF receptor-associated factor 4; tumor necrosis receptor-associated factor 4A; unnamed protein product
Gene Aliases: A530032M13Rik; CART1; MLN62; msp2; RNF83; TRAF4
UniProt ID: (Human) Q9BUZ4, (Mouse) Q61382
Entrez Gene ID: (Human) 9618, (Mouse) 22032, (Rat) 303285
tumor necrosis factor receptor binding
protein binding
zinc ion binding
transferase activity
enzyme binding
protein kinase binding
ubiquitin protein ligase binding
thioesterase binding
signaling adaptor activity
identical protein binding
metal ion binding
WW domain binding
ubiquitin-protein transferase activity
apoptotic process
signal transduction
activation of NF-kappaB-inducing kinase activity
multicellular organism development
respiratory gaseous exchange
protein ubiquitination
respiratory tube development
regulation of apoptotic process
positive regulation of protein kinase activity
positive regulation of JNK cascade
positive regulation of protein homodimerization activity
immune system process
cell surface receptor signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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