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Invitrogen
TRPV4 Polyclonal Antibody
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FIGURE: 1 / 6
TRPV4 Antibody (PA5-77319) in ICC/IF
Immunocytochemistry analysis of TRPV4 in paraformaldehyde-fixed and permeabilized rat dorsal root ganglion. A, D) Samples were probed with TRPV4 polyclonal antibody (Product # PA5-77319) at a dilution of 1:500, and incubated with goat-anti-rabbit-AlexaFluor-555 and Hoechst. B, E) Shows nuclei stained image. C) Shows merged images of Panels A and B. F) Shows merged images of Panels D and E.
Product Details
PA5-77319
Applications
Tested Dilution
Publications
Product Specifications
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide CDGHQQGYAPKWRAEDAPL, corresponding to amino acid residues 853-871 of rat TRPV4
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
40 µg
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitute with 50uL deionized water.
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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