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Invitrogen

GNAQ Polyclonal Antibody

View all (18) GNAQ antibodies

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Product Details

PA5-77989

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human GNAQ. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735864

Product Specific Information

Positive Control: 3xFlag-human GNAQ-transfected 293T

Predicted Reactivity: Zebrafish (93%), Xenopus laevis (96%), Dog (100%), Pig (100%), Chicken (98%), Rhesus Monkey (100%), Bovine (100%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; G alpha q; G protein; GAQ; Gq; guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide binding protein alpha q subunit; guanine nucleotide binding protein, alpha q polypeptide; guanine nucleotide regulatory protein G alpha q; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha; heterotrimeric guanine nucleotide-binding protein alpha q subunit; unnamed protein product

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Gene Aliases: 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; CMAL; CMC1; Dsk1; Dsk10; G-ALPHA-q; Galphaq; GAQ; GNAQ; Gq; GqI; SWS

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UniProt ID: (Human) P50148, (Rat) P82471, (Mouse) P21279

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Entrez Gene ID: (Human) 2776, (Rat) 81666, (Mouse) 14682

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Function(s)
nucleotide binding G-protein coupled receptor binding GTPase activity obsolete small monomeric GTPase activity GTPase activator activity protein binding GTP binding hydrolase activity guanyl nucleotide binding enzyme regulator activity G-protein beta/gamma-subunit complex binding metal ion binding signal transducer activity type 2A serotonin receptor binding protein complex binding heterotrimeric G-protein
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway G-protein coupled acetylcholine receptor signaling pathway glutamate receptor signaling pathway neuropeptide signaling pathway blood coagulation phototransduction, visible light entrainment of circadian clock hormone-mediated signaling pathway regulation of platelet activation response to prostaglandin E protein stabilization regulation of canonical Wnt signaling pathway cellular response to acidic pH adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway skeletal system development action potential negative regulation of protein kinase activity activation of phospholipase C activity heart development metabolic process post-embryonic development neuron remodeling forebrain neuron development regulation of catenin import into nucleus maternal behavior embryonic digit morphogenesis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of potassium ion transport positive regulation of GTPase activity regulation of melanocyte differentiation developmental pigmentation positive regulation of smooth muscle cell proliferation phospholipase C-activating dopamine receptor signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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