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Invitrogen
UCP2 Polyclonal Antibody
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Product Details
PA5-78214
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human UCP2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
3.08 mg/mL
Amount
308 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Human liver
Predicted Reactivity: Rat (100%), Xenopus laevis (100%), Dog (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dicarboxylate carrier SLC25A8; Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein; uncoupling protein 2 (mitochondrial, proton carrier); uncoupling protein 2, mitochondrial
Gene Aliases: BMIQ4; SLC25A8; UCP2; UCPH
UniProt ID: (Human) P55851, (Mouse) P70406
Entrez Gene ID: (Human) 7351, (Mouse) 22228
protein binding
secondary active sulfate transmembrane transporter activity
hydrogen ion transmembrane transporter activity
chloride transmembrane transporter activity
oxaloacetate transmembrane transporter activity
malate transmembrane transporter activity
L-aspartate transmembrane transporter activity
antiporter activity
oxidative phosphorylation uncoupler activity
GDP binding
protein homodimerization activity
phosphate ion uniporter activity
transporter
secondary carrier transporter
mitochondrial fission
response to superoxide
response to hypoxia
glycolytic process
glutamine metabolic process
mitochondrial transport
response to cold
response to glucose
inorganic anion transport
C4-dicarboxylate transport
long-chain fatty acid transport
macrophage differentiation
cellular response to insulin stimulus
cellular response to hormone stimulus
cellular response to amino acid starvation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of mitochondrial membrane potential
transmembrane transport
negative regulation of insulin secretion involved in cellular response to glucose stimulus
response to fatty acid
L-aspartate transmembrane transport
cellular response to lead ion
cellular response to glucose stimulus
malate transmembrane transport
response to dexamethasone
reactive oxygen species metabolic process
liver regeneration
negative regulation of calcium import into the mitochondrion
positive regulation of cold-induced thermogenesis
oxaloacetate(2-) transmembrane transport
sulfate transmembrane transport
chloride transmembrane transport
hydrogen ion transmembrane transport
mitochondrial transmembrane transport
adaptive thermogenesis
transport
positive regulation of cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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