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Invitrogen
WNT7A Polyclonal Antibody
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FIGURE: 1 / 1
WNT7A Antibody (PA5-78227) in WB
WNT7A Polyclonal Antibody detects WNT7A protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract. B. 30 whole cell lysate/extract of V5-human Wnt7A-transfected 293T cells.10 % SDS-PAGE. WNT7A Polyclonal Antibody (Product # PA5-78227) dilution: 1:5,000.
Product Details
PA5-78227
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human WNT7A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: V5-human Wnt7A-transfected 293T cells
Predicted Reactivity: Mouse (100%), Rat (100%), Chicken (94%), Rhesus Monkey (100%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family, member 7A; WNT7a
Gene Aliases: SANTOS; Wnt-7a; WNT7A
UniProt ID: (Human) O00755
Entrez Gene ID: (Human) 7476, (Rat) 114850
embryonic axis specification
cartilage condensation
angiogenesis
chondrocyte differentiation
apoptotic process
neurotransmitter secretion
axonogenesis
synapse assembly
sex differentiation
positive regulation of cell proliferation
tissue development
dorsal/ventral pattern formation
positive regulation of endothelial cell migration
positive regulation of gene expression
skeletal muscle satellite cell activation
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Wnt signaling pathway
cerebellar granule cell differentiation
cell proliferation in forebrain
central nervous system vasculogenesis
establishment of cell polarity
cell differentiation
neuron differentiation
embryonic limb morphogenesis
regulation of axon diameter
response to estradiol
somatic stem cell population maintenance
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
wound healing, spreading of epidermal cells
non-canonical Wnt signaling pathway
synaptic vesicle recycling
regulation of cell proliferation
embryonic digit morphogenesis
negative regulation of apoptotic process
response to estrogen
cell fate commitment
asymmetric protein localization involved in cell fate determination
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
somatic stem cell division
animal organ development
system development
stem cell development
regulation of epithelial cell proliferation
negative regulation of neurogenesis
regulation of axonogenesis
synapse organization
cartilage development
positive regulation of protein metabolic process
positive regulation of synapse assembly
positive regulation of epithelial cell proliferation involved in wound healing
uterus development
oviduct development
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
limb development
establishment of blood-brain barrier
dendritic spine morphogenesis
uterus morphogenesis
secondary palate development
lens fiber cell development
cellular response to transforming growth factor beta stimulus
presynapse assembly
postsynapse assembly
regulation of postsynapse organization
excitatory synapse assembly
positive regulation of excitatory synapse assembly
positive regulation of protein localization to presynapse
regulation of presynapse assembly
regulation of synaptic vesicle exocytosis
positive regulation of excitatory postsynaptic potential
asymmetric protein localization
forelimb morphogenesis
hindlimb morphogenesis
Wnt signaling pathway involved in wound healing, spreading of epidermal cells
wound healing
skin morphogenesis
reproductive structure development
skeletal system morphogenesis
palate development
positive regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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