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Invitrogen

RUVBL2 Polyclonal Antibody

View all (28) RUVBL2 antibodies

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Product Details

PA5-78342

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human RUVBL2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736543

Product Specific Information

Positive Control: 293T, A431, HeLa, HepG2

Predicted Reactivity: Rat (100%), Zebrafish (94%), Xenopus laevis (97%), Pig (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; ECP-51; erythrocyte cytosolic protein, 51-KD; INO80 complex subunit J; p47 protein; Repressing pontin 52; reptin; Reptin 52; reptin52 protein; RuvB (E coli homolog)-like 2; RuvB-like 2; RUVBL2; RUVBL2 protein; TAP54-beta; TIP49b; TIP60-associated protein 54-beta; unnamed protein product

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Gene Aliases: CGI-46; ECP-51; ECP51; INO80J; mp47; p47; REPTIN; RUVBL2; RVB2; TAP54-beta; TIH2; TIP48; TIP49B

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UniProt ID: (Human) Q9Y230, (Mouse) Q9WTM5

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Entrez Gene ID: (Human) 10856, (Mouse) 20174

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Function(s)
nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding TFIID-class transcription factor binding DNA helicase activity transcription corepressor activity helicase activity protein binding ATP binding beta-catenin binding DNA-dependent ATPase activity hydrolase activity ATPase activity TBP-class protein binding chromatin DNA binding identical protein binding protein homodimerization activity ADP binding unfolded protein binding ATPase binding promoter-enhancer loop anchoring activity RNA polymerase II distal enhancer sequence-specific DNA binding damaged DNA binding ATP-dependent 5'-3' DNA helicase activity
Process(es)
DNA repair DNA recombination chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated cellular response to DNA damage stimulus chromatin modification DNA duplex unwinding cellular response to UV positive regulation of histone acetylation histone H4 acetylation histone H2A acetylation positive regulation of transcription from RNA polymerase II promoter establishment of protein localization to chromatin cellular response to estradiol stimulus transcriptional activation by promoter-enhancer looping negative regulation of estrogen receptor binding box C/D snoRNP assembly telomere maintenance regulation of DNA replication regulation of DNA repair chromatin organization regulation of transcription from RNA polymerase II promoter protein folding regulation of chromosome organization regulation of apoptotic process positive regulation of DNA repair negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of embryonic development protein stabilization regulation of cell cycle regulation of DNA strand elongation negative regulation of canonical Wnt signaling pathway telomerase RNA localization to Cajal body positive regulation of telomere maintenance in response to DNA damage positive regulation of double-strand break repair via homologous recombination regulation of double-strand break repair
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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