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Invitrogen

DHX36 Polyclonal Antibody

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DHX36 Polyclonal Antibody

Product Details

PA5-78644

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
- -

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human DHX36. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Amount

60 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735719

Product Specific Information

Positive Control: 293T, A431, HeLa, HepG2

Predicted reactivity: Mouse (82%), Rat (80%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. DHX36 (DEAH box protein 36), also known as MLE-like protein 1 and RNA helicase associated with AU-rich element ARE (RHAU), belongs to RNA helicase of the DEAH family and may function in sex development and spermatogenesis. It is expressed in testis and is evolutionary conserved with true orthologs in almost all animal species. DHX36 plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. DHX36 is required for early embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Asp-Glu-Ala-His; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DEAH-box protein 36; G4 resolvase-1; G4-resolvase-1; G4R1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein; unnamed protein product

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Gene Aliases: 2810407E23Rik; AI452301; AU022184; DDX36; DHX36; G4R1; KIAA1488; mKIAA1488; MLEL1; RHAU

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UniProt ID: (Human) Q9H2U1, (Rat) D4A2Z8, (Mouse) Q8VHK9

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Entrez Gene ID: (Human) 170506, (Rat) 310461, (Mouse) 72162

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Function(s)
nucleotide binding magnesium ion binding transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding G-quadruplex RNA binding nucleic acid binding DNA binding DNA helicase activity single-stranded DNA binding RNA binding RNA helicase activity double-stranded RNA binding mRNA 3'-UTR binding helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity ATPase activity mRNA 3'-UTR AU-rich region binding histone deacetylase binding metal ion binding mRNA 5'-UTR binding G-quadruplex DNA binding telomerase RNA binding pre-miRNA binding catalytic activity, acting on a nucleic acid core promoter binding ATP-dependent RNA helicase activity transcription regulatory region DNA binding poly(A) RNA binding ATP-dependent helicase activity RNA helicase
Process(es)
ossification immune system process positive regulation of myeloid dendritic cell cytokine production regulation of transcription from RNA polymerase III promoter regulation of translation spermatogenesis response to virus positive regulation of gene expression negative regulation of translation cell differentiation positive regulation of mRNA 3'-end processing positive regulation of telomere maintenance positive regulation of interferon-alpha production cellular response to heat cellular response to UV positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA regulation of mRNA stability innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development defense response to virus positive regulation of cardioblast differentiation positive regulation of transcription initiation from RNA polymerase II promoter positive regulation of dendritic spine morphogenesis 3'-UTR-mediated mRNA destabilization telomerase RNA stabilization positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of hematopoietic progenitor cell differentiation cellular response to arsenite ion positive regulation of telomere maintenance via telomere lengthening positive regulation of intracellular mRNA localization positive regulation of cytoplasmic translation RNA processing RNA secondary structure unwinding transcription, DNA-templated regulation of transcription, DNA-templated
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