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Invitrogen
ASXL1 Polyclonal Antibody
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FIGURE: 1 / 2
ASXL1 Antibody (PA5-78828) in WB
Western blot analysis of ASXL1 using ASXL1 Polyclonal Antibody (Product # PA5-78828). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: human 293T whole cell lysates. Lane 2: human MCF-7 whole cell lysates. Lane 3: human CACO-2 whole cell lysates. Lane 4: rat C6 whole cell lysates. Lane 5: mouse NIH/3T3 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocell... View More
Product Details
PA5-78828
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human ASXL1 (KKERTWAEAARLVLENYSDAPMTPKQILQVIEAE).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human 293T whole cell, human MCF-7 whole cell, human CACO-2 whole cell, rat C6 whole cell, mouse NIH/3T3 whole cell. Flow: HepG2 cell.
Target Information
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: additional sex combs like 1; additional sex combs like 1, transcriptional regulator; additional sex combs like transcriptional regulator 1; Additional sex combs-like protein 1; MGC117280; MGC71111; Polycomb group protein ASXL1; putative Polycomb group protein ASXL1; unnamed protein product
Gene Aliases: ASXL1; BOPS; KIAA0978; MDS; mKIAA0978; RGD1561878
UniProt ID: (Human) Q8IXJ9, (Mouse) P59598
Entrez Gene ID: (Human) 171023, (Mouse) 228790, (Rat) 311553
cell morphogenesis
heart morphogenesis
chromatin organization
regulation of transcription, DNA-templated
organ morphogenesis
hemopoiesis
response to retinoic acid
negative regulation of peroxisome proliferator activated receptor signaling pathway
regulation of kidney size
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
hematopoietic or lymphoid organ development
thymus development
bone marrow development
homeostasis of number of cells
bone development
lung saccule development
glomerular visceral epithelial cell development
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
chromatin modification
monoubiquitinated histone H2A deubiquitination
negative regulation of retinoic acid receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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