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Invitrogen

GSTP1 Polyclonal Antibody

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GSTP1 Polyclonal Antibody

Product Details

PA5-79340

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived rat GST3 / GST pi recombinant protein (Position: P2-Q210).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746456

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human 293T whole cell, human Jurkat whole cell, rat liver tissue, rat stomach tissue, mouse liver tissue, mouse stomach tissue. IHC: rat kidney tissue, rat liver tissue. ICC/IF: NRK cell.

Target Information

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Chain 7; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III; Glutathione S-transferase P; Glutathione S-transferase P 1; glutathione S-transferase pi 2; glutathione S-transferase, pi 2; Glutathione-S-transferase placental enzyme pi type; glutathione-S-transferase, pi 1; Glutathione-S-transferase, placental enzyme pi type; GST 7-7; GST class-pi; Gst p-1; Gst P1; GST YF-YF; GST-piB; GSTP1; GSTP1-1; HGNC:4638; Preadipocyte growth factor; unnamed protein product

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Gene Aliases: DFN7; FAEES3; GST-P; GST3; GSTP; GSTP1; Gstp2; GstpiB; HEL-S-22; PI

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UniProt ID: (Human) P09211, (Rat) P04906, (Mouse) P19157

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Entrez Gene ID: (Human) 2950, (Rat) 24426, (Mouse) 14870

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Function(s)
glutathione transferase activity glutathione peroxidase activity fatty acid binding protein binding JUN kinase binding toxic substance binding transferase activity protein kinase binding protein serine/threonine kinase inhibitor activity S-nitrosoglutathione binding dinitrosyl-iron complex binding nitric oxide binding drug binding kinase regulator activity glutathione binding transferase
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to reactive oxygen species negative regulation of acute inflammatory response lipid metabolic process prostaglandin metabolic process glutathione metabolic process xenobiotic metabolic process central nervous system development response to toxic substance negative regulation of tumor necrosis factor-mediated signaling pathway oligodendrocyte development organ regeneration response to nutrient levels response to estradiol negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production cellular response to insulin stimulus regulation of stress-activated MAPK cascade negative regulation of stress-activated MAPK cascade positive regulation of superoxide anion generation response to L-ascorbic acid common myeloid progenitor cell proliferation nitric oxide storage negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid negative regulation of MAPK cascade linoleic acid metabolic process response to ethanol negative regulation of JNK cascade negative regulation of fibroblast proliferation hepoxilin biosynthetic process regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to lipopolysaccharide cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to cell-matrix adhesion negative regulation of monocyte chemotactic protein-1 production negative regulation of smooth muscle cell chemotaxis cellular oxidant detoxification glutathione derivative biosynthetic process negative regulation of vascular smooth muscle cell proliferation negative regulation of extrinsic apoptotic signaling pathway negative regulation of protein kinase activity negative regulation of biosynthetic process negative regulation of MAP kinase activity negative regulation of JUN kinase activity response to mercury ion negative regulation of nitric-oxide synthase biosynthetic process negative regulation of peroxidase activity metabolic process negative regulation of neutrophil aggregation
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