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Invitrogen
Laminin gamma-1,2,3 Polyclonal Antibody
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FIGURE: 1 / 10
Laminin gamma-1,2,3 Antibody (PA5-79576) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Laminin gamma-1,2,3 in paraffin-embedded section of mouse skeletal muscle tissue using Laminin gamma-1,2,3 Polyclonal Antibody (Product # PA5-79576). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody a... View More
Product Details
PA5-79576
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide mixture of laminin gamma1,2,3 (NKLNEIEGSLNKAKDEMKAS; DLEERVRRQRNHLHLLETSI; LQLDSHGALHHKLRQLEEES).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts will all 3 isoforms of Laminin gamma: Laminin gamma-1, gamma-2 and gamma-3.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human A431 whole cell, human A549 whole cell, human PC-3 whole cell, human CACO-2 whole cell, rat NRK whole cell, rat RH35 whole cell, mouse NIH/3T3 whole cell, mouse HEPA1-6 whole cell. IHC: mouse heart tissue, mouse kidney tissue, rat cardiac muscle tissue, rat kidney tissue.
Target Information
Extracellular matrix (ECM) surrounds and separates most tissue compartments, determines tissue architecture and dynamically interacts with its surrounding cells. The basement membrane is a part of the ECM and is composed of collagens, proteoglycans, elastin and several glycoproteins of which laminin is the most abundant. Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains Dystroglycan is a major laminin receptor in muscle and epithelia, and nidogen is a high-affinity laminin-binding protein important for basement-membrane assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basement membrane protein; BM600-100kDa; Cell-scattering factor 140 kDa subunit; CSF 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Ladsin 140 kDa subunit; lamimin, gamma 2; Laminin B2 chain; laminin B2 precursor; Laminin B2t chain; laminin gamma2 chain; Laminin subunit gamma-1; Laminin subunit gamma-2; Laminin subunit gamma-3; laminin, gamma 1 (formerly LAMB2); laminin, gamma 2; laminin, gamma 3; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-5 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; Large adhesive scatter factor 140 kDa subunit; Nicein subunit gamma; nicein, 100kD; nicein, 100kDa; S-LAM gamma; S-laminin subunit gamma; unnamed protein product
Gene Aliases: AA589349; AI562206; AW240805; B2e; B2T; BM600; CSF; EBR2; EBR2A; JEB3A; JEB3B; LAMB2; LAMB2T; LAMC1; LAMC2; LAMC3; LAMNB2; OCCM
UniProt ID: (Human) P11047, (Human) Q13753, (Human) Q9Y6N6, (Mouse) Q9R0B6
Entrez Gene ID: (Human) 3915, (Human) 3918, (Human) 10319, (Mouse) 226519, (Rat) 117036, (Mouse) 16782, (Rat) 192362, (Rat) 311862, (Mouse) 23928
cell adhesion
endoderm development
tissue development
cell migration
extracellular matrix disassembly
hemidesmosome assembly
substrate adhesion-dependent cell spreading
maintenance of blood-brain barrier
positive regulation of cell adhesion
positive regulation of epithelial cell proliferation
positive regulation of muscle cell differentiation
protein-containing complex assembly
regulation of basement membrane organization
positive regulation of integrin-mediated signaling pathway
positive regulation of cell proliferation
epidermis development
positive regulation of cell migration
cell morphogenesis
visual perception
astrocyte development
retina development in camera-type eye
protein complex assembly
neuron projection development
biological_process
cell morphogenesis involved in differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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