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Invitrogen

NME1 Polyclonal Antibody

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NME1 Polyclonal Antibody

Product Details

PA5-79742

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

0.5-1 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human NM23A (137-152aa EELVDYTSCAQNWIYE).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746857

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human A549 whole cell, human MCF-7 whole cell, human Hela whole cell, human PC-3 whole cell, rat brain tissue.

Target Information

NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in the gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; expressed in non-metastatic cells 1 protein; expressed in non-metastatic cells 1 protein (NM23A) (nucleoside diphosphate kinase); expressed in non-metastatic cells 1, protein; expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase); Farnesyl diphosphate kinase NME1; GAAD; Granzyme A activated DNase (GAAD); granzyme A-activated DNase; GZMA activated DNase; Histidine protein kinase NDK; Histidine protein kinase NME1; included; Metastasis inhibition factor NM23; NDK A; NDK1; NDP kinase A; NDP kinase beta; NDPK-A; NM23-H1; nm23-M1; NM23H1; NM23H1B; NME1; NME1-NME2 spliced read-through transcript; non-metastatic cells 1, protein (NM23A) expressed in; Non-specific serine/threonine protein kinase NME1; Nucleoside diphoshate kinase 1; Nucleoside diphosphate kinase A; nucleoside-diphosphate kinase 1; nucleotide diphosphate kinase; nucloside diphosphate kinase; Putative 3'-5'-DNA exonuclease NDK1; Putative granzyme A-activated DNA endonuclease; Tumor metastatic process-associated protein; unnamed protein product

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Gene Aliases: AL024257; AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1; NM23-M1; NM23A; NME1

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UniProt ID: (Human) P15531, (Mouse) P15532, (Rat) Q05982

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Entrez Gene ID: (Human) 4830, (Mouse) 18102, (Rat) 191575

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Function(s)
nucleotide binding magnesium ion binding DNA binding RNA binding endodeoxyribonuclease activity deoxyribonuclease activity nucleoside diphosphate kinase activity protein histidine kinase activity protein binding ATP binding 3'-5'-exodeoxyribonuclease activity kinase activity transferase activity phosphotransferase activity, phosphate group as acceptor GDP binding identical protein binding ribosomal small subunit binding ADP binding metal ion binding farnesyl diphosphate kinase activity coenzyme A binding succinyl-CoA binding acetyl-CoA binding RNA polymerase II regulatory region sequence-specific DNA binding single-stranded DNA binding GTP binding intermediate filament binding enzyme binding protein kinase binding gamma-tubulin binding poly(A) RNA binding kinase
Process(es)
GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process DNA catabolic process apoptotic DNA fragmentation isoprenoid metabolic process endocytosis nervous system development lactation negative regulation of cell proliferation nucleotide metabolic process nucleoside diphosphate metabolic process nucleoside triphosphate biosynthetic process cell differentiation mammary gland development protein hexamerization regulation of fatty acid biosynthetic process regulation of apoptotic process ITP biosynthetic process acetyl-CoA catabolic process positive regulation of epithelial cell proliferation negative regulation of myeloid leukocyte differentiation purine nucleotide metabolic process nucleoside diphosphate phosphorylation pyrimidine nucleotide metabolic process DNA metabolic process negative regulation of gene expression positive regulation of neuron projection development phosphorylation positive regulation of DNA binding nucleic acid phosphodiester bond hydrolysis integrin-mediated signaling pathway response to amine hippocampus development response to testosterone cellular response to drug response to drug negative regulation of apoptotic process positive regulation of keratinocyte differentiation positive regulation of transcription from RNA polymerase II promoter response to cAMP cellular response to glucose stimulus cellular response to fatty acid
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