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Invitrogen
NOV Polyclonal Antibody
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FIGURE: 1 / 3
NOV Antibody (PA5-80859) in IHC (P)
Immunohistochemical staining of human NOV in human brain with NOV Polyclonal Antibody (Product # PA5-80859, 1:2,500 dilution, formalin-fixed paraffin embedded sections). Left panel: tissue incubated with primary antibody. Right panel: tissue incubated with mixture of primary antibody and antigen (recombinant protein).
Product Details
PA5-80859
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CCN3/NOV/IGFBP9 protein (Met1-Met357)
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human CCN3/NOV/IGFBP9.
Target Information
NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell-surface integrins, and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCN family member 3; Cellular communication network factor 3; IBP-9; IGF-binding protein 9; Insulin-like growth factor-binding protein 9; Nephro blastoma-overexpressed gene protein homolog; nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein homolog; NOV; NovH; Protein NOV homolog; unnamed protein product
Gene Aliases: CCN3; IBP-9; IGFBP-9; IGFBP9; NOV; NOVH
UniProt ID: (Human) P48745
Entrez Gene ID: (Human) 4856
angiogenesis
chondrocyte differentiation
cell adhesion
signal transduction
fibroblast migration
negative regulation of myotube differentiation
smooth muscle cell migration
negative regulation of cell growth
cell adhesion mediated by integrin
endothelial cell chemotaxis
type B pancreatic cell proliferation
positive regulation of cell differentiation
positive regulation of Notch signaling pathway
positive regulation of ossification
negative regulation of insulin secretion
smooth muscle cell proliferation
negative regulation of inflammatory response
regulation of developmental process
cell chemotaxis
negative regulation of SMAD protein import into nucleus
hematopoietic stem cell homeostasis
endothelial cell-cell adhesion
negative regulation of monocyte chemotaxis
negative regulation of NIK/NF-kappaB signaling
negative regulation of chondrocyte proliferation
negative regulation of sensory perception of pain
bone regeneration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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