Search
Invitrogen
CES1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 8
CES1 Antibody (PA5-82453) in IHC (P)
Immunohistochemistry analysis of CES1 in human cerebral cortex, liver, prostate and upper gastrointestinal. Samples were incubated with CES1 polyclonal antibody (Product # PA5-82453). Shows similar protein distribution across tissues to independent CES1 antibody (Product # PA5-83836) (B).
Product Details
PA5-82453
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CES1. Recombinant protein control fragment (Product #RP-88976).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VTIFGESAGG ESVSVLVLSP LAKNLFHRAI SESGVALTSV LVKKGDVKPL AEQIAITAGC KTTTSAVMVH CLRQKTEEEL LETTLKMKFL SLDLQGDPRE SQPLLGTVID GMLLLKTPEE LQAERNFHTV P
Highest antigen sequence indentity to the following orthologs: Mouse - 74%, Rat - 73%.
Target Information
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ACAT; acyl coenzyme A:cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 2 (liver); carboxylesterase; ACAT; CE-1; CEH; Cholesteryl ester hydrolase; Cocaine carboxylesterase; Egasyn; ER-resident carboxylesterase; HMSE; human monocyte/macrophage serine esterase 1; Liver carboxylesterase 1; Methylumbelliferyl-acetate deacetylase 1; MGC117365; Monocyte/macrophage serine esterase; REH; Retinyl ester hydrolase; Serine esterase 1; TGH; triacylglycero; Triacylglycerol hydrolase; unnamed protein product
Gene Aliases: ACAT; CE-1; CEH; CES1; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
UniProt ID: (Human) P23141
Entrez Gene ID: (Human) 1066
lipid metabolic process
cholesterol biosynthetic process
cholesterol metabolic process
response to toxic substance
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
lipid catabolic process
epithelial cell differentiation
cholesterol homeostasis
reverse cholesterol transport
medium-chain fatty acid metabolic process
regulation of bile acid biosynthetic process
cellular response to cholesterol
cellular response to low-density lipoprotein particle stimulus
cholesterol ester hydrolysis involved in cholesterol transport
positive regulation of cholesterol metabolic process
regulation of bile acid secretion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support