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Invitrogen
SPIN1 Polyclonal Antibody
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Product Details
PA5-84790
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SPIN1. Recombinant protein control fragment (Product #RP-107652).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNI
Highest antigen sequence indentity to the following orthologs: Rat - 98%, Mouse - 98%.
Target Information
SPIN1 (spindlin 1), also known as SPIN or ovarian cancer-related protein (OCR), is a 262 amino acid nuclear protein suggested to play a role in regulation of the cell-cycle during the transition from gamete to embryo. A member of the SPIN/STSY family, SPIN1 localizes to interphase nucleus and mitotic chromosomes, and is modified by phosphorylation in a cell-cycle-dependent fashion. A meiotic spindle-binding protein, SPIN1 overexpression has been shown to cause defects in mitotic spindles, thereby resulting in chromosome instability and potential tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ovarian cancer-related (OCR) protein; Ovarian cancer-related protein; SPIN; Spindlin-1; Spindlin1; unnamed protein product
Gene Aliases: OCR; SPIN; SPIN1; TDRD24
UniProt ID: (Human) Q9Y657
Entrez Gene ID: (Human) 10927
chromatin organization
regulation of transcription, DNA-templated
gamete generation
rRNA transcription
Wnt signaling pathway
positive regulation of Wnt signaling pathway
positive regulation of transcription, DNA-templated
meiotic cell cycle
protein localization to chromatin
transposable element silencing by piRNA-mediated DNA methylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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