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Invitrogen

NMDAR2A Polyclonal Antibody

View all (37) NMDAR2A antibodies

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Product Details

PA5-85391

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the Intracellular domain of human NMDAR2A. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792533

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (90%), Rat (90%), Chimpanzee (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA 2A; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531; unnamed protein product

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Gene Aliases: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A

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UniProt ID: (Human) Q12879, (Rat) Q00959

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Entrez Gene ID: (Human) 2903, (Rat) 24409

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity cation channel activity calcium channel activity protein binding zinc ion binding ligand-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity metal ion binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ionotropic glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity glutamate binding protein kinase binding voltage-gated cation channel activity protein complex binding glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity cell adhesion molecule binding ATPase binding scaffold protein binding transmembrane signal receptor
Process(es)
startle response response to amphetamine ion transport calcium ion transport glutamate receptor signaling pathway chemical synaptic transmission brain development learning or memory learning memory visual learning response to xenobiotic stimulus response to wounding sensory perception of pain calcium-mediated signaling neurogenesis protein catabolic process sleep directional locomotion ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic sodium ion transmembrane transport locomotion negative regulation of protein catabolic process regulation of membrane potential dopamine metabolic process serotonin metabolic process positive regulation of apoptotic process response to ethanol regulation of synaptic plasticity regulation of neuronal synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission protein localization to postsynaptic membrane regulation of cation transmembrane transport cellular response to beta-amyloid positive regulation of excitatory postsynaptic potential action potential cation transport protein localization response to light stimulus response to carbohydrate response to manganese ion positive regulation of cell death response to organic cyclic compound response to amine spinal cord development hippocampus development cerebral cortex development regulation of ion transmembrane transport response to cocaine response to drug regulation of long-term neuronal synaptic plasticity rhythmic process detection of mechanical stimulus involved in sensory perception of pain protein tetramerization response to calcium ion response to methylmercury response to other organism regulation of sensory perception of pain response to ammonium ion response to fungicide cellular response to amino acid stimulus cellular response to magnesium ion cellular response to manganese ion cellular response to zinc ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid
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