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Invitrogen
CCR7 Polyclonal Antibody
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FIGURE: 1 / 4
CCR7 Antibody (PA5-85613) in WB
Western blot analysis of CCR7 in whole cell extract using CCR7 polyclonal antibody (Product # PA5-85613) using 30 µg of sample at a dilution of 1:500. Sample was then incubated with Hoechst secondary antibody. Prior to incubation with primary antibody, the sample was separated on 10% SDS-PAGE.
Product Details
PA5-85613
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human CCR7.
Conjugate
Form
Liquid
Concentration
1.06 mg/mL
Amount
106 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (87%), Rat (88%), Pig (93%), Rhesus Monkey (100%), Bovine (95%).
Positive Control: HeLa, HepG2, MCF-7.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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