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Invitrogen

Thrombospondin 1 Polyclonal Antibody

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View all (27) Thrombospondin 1 antibodies

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Thrombospondin 1 Polyclonal Antibody

Product Details

PA5-85678

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human Thrombospondin 1. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.2 mg/mL

Amount

220 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792817

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (90%), Rat (95%), Pig (97%), Bovine (95%).

Positive Control: HUVEC.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Glycoprotein G; Thrombospondin; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; unnamed protein product

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Gene Aliases: THBS; THBS-1; THBS1; TSP; TSP-1; TSP1

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UniProt ID: (Human) P07996

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Entrez Gene ID: (Human) 7057

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Function(s)
phosphatidylserine binding fibronectin binding protease binding endopeptidase inhibitor activity integrin binding extracellular matrix structural constituent calcium ion binding protein binding heparin binding fibroblast growth factor binding low-density lipoprotein particle binding protein homodimerization activity laminin binding proteoglycan binding transforming growth factor beta binding extracellular matrix binding fibrinogen binding collagen V binding
Process(es)
angiogenesis response to hypoxia negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion sprouting angiogenesis chronic inflammatory response negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation positive regulation of immune system process apoptotic process inflammatory response immune response response to unfolded protein cell adhesion positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus response to mechanical stimulus response to glucose positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of plasma membrane long-chain fatty acid transport negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration regulation of cell-substrate adhesion cell migration negative regulation of angiogenesis positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway response to magnesium ion response to progesterone negative regulation of interleukin-10 production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of transforming growth factor beta1 production response to testosterone cellular response to heat response to endoplasmic reticulum stress nitric oxide-cGMP-mediated signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation positive regulation of macrophage activation negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain blood vessel morphogenesis positive regulation of smooth muscle cell proliferation positive regulation of chemotaxis response to calcium ion negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of fibrinolysis cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of transforming growth factor beta production blood coagulation, fibrin clot formation negative regulation of cell migration involved in sprouting angiogenesis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis negative regulation of extrinsic apoptotic signaling pathway
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