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Invitrogen
IFN beta Polyclonal Antibody
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Product Details
PA5-86768
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in Human IFNB1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; Interferon b; Interferon beta; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1; unnamed protein product
Gene Aliases: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574, (Rat) P70499, (Mouse) P01575
Entrez Gene ID: (Human) 3456, (Rat) 24481, (Mouse) 15977
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
negative regulation of immune system process
regulation of transcription from RNA polymerase II promoter
response to stress
defense response
immune response
humoral immune response
signal transduction
cell surface receptor signaling pathway
JAK-STAT cascade
response to virus
positive regulation of metabolic process
positive regulation of autophagy
cytokine-mediated signaling pathway
natural killer cell activation
cellular response to interferon-beta
B cell proliferation
response to exogenous dsRNA
negative regulation of viral genome replication
innate immune response
positive regulation of innate immune response
leukocyte activation
regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of multicellular organismal process
defense response to virus
type I interferon signaling pathway
neuron cellular homeostasis
cellular response to dsRNA
cellular response to exogenous dsRNA
receptor signaling pathway via STAT
cellular response to virus
negative regulation of Lewy body formation
antiviral innate immune response
positive regulation of protein localization to nucleus
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
defense response to bacterium
cellular response to dexamethasone stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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