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Invitrogen

HSPA1A Polyclonal Antibody

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HSPA1A Polyclonal Antibody

Product Details

PA5-87170

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1000-1:3000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to a sequence within amino acids 500-600 of human HSP70/HSPA1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803920

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 68 kDa heat shock protein; dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; epididymis secretory sperm binding protein; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; Heat shock 70 kDa protein 3; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock protein 70-1; Heat shock protein family A member 1A; Heat shock protein family A member 1B; heat shock protein, 70 kDa 3; heat shock-induced protein; Hsp68; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70.1/2; HSP70.1/HSP70.2; HSP70.3; inducible heat shock protein 70; unnamed protein product

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Gene Aliases: HEL-S-103; hsp68; HSP70; HSP70-1; HSP70-1A; HSP70-2; Hsp70-3; HSP70.1; HSP70.2; Hsp70.3; Hsp70A1; HSP70I; HSP72; HSPA1; HSPA1A; HSPA1B; Hspa2; HSX70

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UniProt ID: (Human) P0DMV8, (Mouse) Q61696, (Rat) P0DMW0

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Entrez Gene ID: (Human) 3303, (Mouse) 193740, (Rat) 24472

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Function(s)
nucleotide binding virus receptor activity G-protein coupled receptor binding transcription corepressor activity RNA binding receptor binding protein binding ATP binding ATPase activity enzyme binding heat shock protein binding denatured protein binding ubiquitin protein ligase binding death receptor agonist activity histone deacetylase binding protein binding involved in protein folding cadherin binding receptor agonist activity unfolded protein binding misfolded protein binding C3HC4-type RING finger domain binding disordered domain specific binding transcription regulator inhibitor activity ATP-dependent protein disaggregase activity ATP-dependent protein folding chaperone protease binding double-stranded RNA binding ATPase activity, coupled poly(A) RNA binding protein N-terminus binding NF-kappaB binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter mRNA catabolic process protein folding response to unfolded protein lysosomal transport negative regulation of cell proliferation positive regulation of gene expression negative regulation of cell growth negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response regulation of protein ubiquitination negative regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production positive regulation of RNA splicing cellular response to oxidative stress cellular response to heat cellular response to unfolded protein protein refolding negative regulation of apoptotic process positive regulation of erythrocyte differentiation ATP metabolic process viral entry into host cell protein stabilization positive regulation of NF-kappaB transcription factor activity chaperone-mediated protein complex assembly cellular heat acclimation positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to steroid hormone stimulus positive regulation of microtubule nucleation negative regulation of inclusion body assembly negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitotic spindle assembly negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand telomere maintenance DNA repair response to heat positive regulation of T cell mediated cytotoxicity defense response binding of sperm to zona pellucida regulation of cell death negative regulation of myeloid cell apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of vasoconstriction negative regulation of cell death
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