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Invitrogen
SGK1 Polyclonal Antibody
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Product Details
PA5-87746
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa, Jurkat, 293T, HepG2, Mouse kidney, rat ovary, rat thymus; Cellular Location: Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Mitochondrion, Nucleus
Target Information
SGK (SGK1) is a serine/threonine kinase that may be a transcriptional target for p38/MAPK in hepatoma cells. SGK plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N-terminal variant of classic Sgk1; serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum and glucocorticoid-dependent protein kinase; Serum/glucocorticoid-regulated kinase 1; Sgk1_i2; unnamed protein product
Gene Aliases: SGK; SGK1
UniProt ID: (Human) O00141, (Mouse) Q9WVC6
Entrez Gene ID: (Human) 6446, (Mouse) 20393, (Rat) 29517
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
calcium channel regulator activity
protein binding
ATP binding
potassium channel regulator activity
kinase activity
transferase activity
sodium channel regulator activity
chloride channel regulator activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
3-phosphoinositide-dependent protein kinase binding
cofactor binding
tau protein binding
phosphatidylinositol binding
protein modifying enzyme
regulation of cell growth
protein phosphorylation
sodium ion transport
apoptotic process
cellular response to DNA damage stimulus
long-term memory
regulation of blood pressure
regulation of cell migration
positive regulation of transporter activity
intracellular signal transduction
regulation of cell proliferation
regulation of apoptotic process
neuron projection morphogenesis
regulation of catalytic activity
regulation of sequence-specific DNA binding transcription factor activity
regulation of gastric acid secretion
renal sodium ion absorption
regulation of signal transduction by p53 class mediator
cellular response to aldosterone
cellular sodium ion homeostasis
microtubule depolymerization
visual learning
positive regulation of sodium ion transport
phosphorylation
peptidyl-serine phosphorylation
positive regulation of cell growth
negative regulation of microtubule polymerization
cellular response to insulin stimulus
regulation of protein localization
negative regulation of apoptotic process
glucocorticoid mediated signaling pathway
positive regulation of dendrite morphogenesis
regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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