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Invitrogen
Cardiac Troponin T Polyclonal Antibody
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FIGURE: 1 / 1
Cardiac Troponin T Antibody (PA5-88102) in WB
Western blot analysis of Cardiac Troponin T in extracts of various cell lines. Samples were incubated with Cardiac Troponin T Polyclonal antibody (Product # PA5-88102) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-88102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Amount
101 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL; Positive Samples: mouse heart, rat heart
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T2; cTnT; MGC3889; TnTc; Troponin T cardiac; Troponin T, cardiac muscle; Troponin T2; troponin T2, cardiac
Gene Aliases: cTnT; Ctt; CTTG; RATCTTG; Tnnt2; Tnnt3; Tnt
UniProt ID: (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Rat) 24837, (Mouse) 21956
muscle contraction
regulation of muscle contraction
heart development
regulation of heart contraction
metabolic process
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
regulation of muscle filament sliding speed
sarcomere organization
protein heterooligomerization
response to calcium ion
actin crosslink formation
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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