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Invitrogen
SUFU Polyclonal Antibody
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Product Details
PA5-89230
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.85 mg/mL
Amount
85 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse testis, Rat kidney; Cellular Location: Cytoplasm, Nucleus
Target Information
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: negative regulator of hedgehog signaling; novel; novel PEST-containing protein; novel; su(fu); OTTHUMP00000020377; OTTHUMP00000020378; OTTHUMP00000020379; RP11-47A8.1; SUFUH; Suppressor of fused homolog; unnamed protein product
Gene Aliases: BCNS2; JBTS32; PRO1280; Su(fu); SUFU; SUFUH; SUFUXL; UNQ650/PRO1280
UniProt ID: (Human) Q9UMX1, (Mouse) Q9Z0P7
Entrez Gene ID: (Human) 51684, (Rat) 361769, (Mouse) 24069
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
heart looping
ventricular septum development
regulation of transcription, DNA-templated
signal transduction
smoothened signaling pathway
spermatid development
determination of left/right symmetry
spinal cord dorsal/ventral patterning
smoothened signaling pathway involved in ventral spinal cord interneuron specification
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
aorta development
negative regulation of protein import into nucleus
skin development
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
coronary vasculature development
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of cellular response to drug
biological_process
cytoplasmic sequestering of transcription factor
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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