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Invitrogen
Adenylate Kinase 4 Polyclonal Antibody
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FIGURE: 1 / 2
Adenylate Kinase 4 Antibody (PA5-89247) in WB
Western blot analysis of Adenylate Kinase 4 in extracts of various cell lines. Samples were incubated with Adenylate Kinase 4 Polyclonal antibody (Product # PA5-89247) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-89247
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.85 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY; Positive Samples: HepG2, Raji, HeLa, SW480, Mouse liver, Mouse kidney; Cellular Location: Mitochondrion matrix
Target Information
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenylate kinase 3 alpha-like 1; Adenylate kinase 3-like; adenylate kinase 3-like 1; Adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4, mitochondrial; AK 4; AK3; ATP-AMP transphosphorylase; epididymis secretory sperm binding protein; GTP:AMP phosphotransferase AK4; GTP:AMP phosphotransferase AK4, mitochondrial; mitochondrial adenylate kinase-3; nucleoside-triphosphate-adenylate kinase; RP4-686B20.1; unnamed protein product
Gene Aliases: AK 4; Ak-3; Ak-4; AK3; Ak3b; AK3L1; AK3L2; AK4; D4Ertd274e
UniProt ID: (Human) P27144, (Mouse) Q9WUR9
Entrez Gene ID: (Human) 205, (Mouse) 11639
nucleotide binding
adenylate kinase activity
nucleoside diphosphate kinase activity
protein binding
ATP binding
GTP binding
kinase activity
transferase activity
phosphotransferase activity, phosphate group as acceptor
nucleobase-containing compound kinase activity
CMP kinase activity
dCMP kinase activity
nucleoside triphosphate adenylate kinase activity
dAMP kinase activity
nucleoside phosphate kinase activity
nucleotide kinase
regulation of oxidative phosphorylation
nucleobase-containing compound metabolic process
ADP biosynthetic process
nucleotide metabolic process
nucleoside monophosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside diphosphate biosynthetic process
nucleobase-containing small molecule interconversion
AMP metabolic process
ATP metabolic process
GTP metabolic process
nucleoside monophosphate phosphorylation
cellular response to hypoxia
nucleoside diphosphate phosphorylation
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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