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Invitrogen

CYP1B1 Polyclonal Antibody

View all (16) CYP1B1 antibodies

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CYP1B1 Polyclonal Antibody

Product Details

PA5-89424

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CYP1B1 (NP_0000952)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.46 mg/mL

Amount

146 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805564

Product Specific Information

Immunogen sequence: MGTSLSPNDP WPLNPLSIQQ TTLLLLLSVL ATVHVGQRLL RQRRRQLRSA PPGPFAWPLI GNAAAVGQAA HLSFARLARR YGDVFQIRLG SCPIVVLNGE RAIHQALVQQ GSAFADRPAF ASFRVVSGGR SMAFGHYSEH WKVQRRAAHS MMRNFFTRQP RSRQVLEGHV LSEARELVAL LVRGSADGAF LDPRPLTVVA VANVMSAVCF GCRYSHDDPE FRELLSHNEE FGRTVGAGSL VDVMPWLQYF PNPVRTVFRE; Positive Samples: A-549, MCF7, HL-60, HT-29, Mouse kidney, Mouse heart, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion, Peripheral membrane protein

Target Information

CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CYPIB1; Cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); Cytochrome P450CMEF; Cytochrome P450EF; Cytochrome P450RAP; dioxin-inducible cytochrome p450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P450RAP; unnamed protein product; xenobiotic monooxygenase

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Gene Aliases: ASGD6; CP1B; Cyp1-b1; CYP1B1; CYPIB1; GLC3A; P4501B1

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UniProt ID: (Human) Q16678, (Rat) Q64678, (Mouse) Q64429

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Entrez Gene ID: (Human) 1545, (Rat) 25426, (Mouse) 13078

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Function(s)
monooxygenase activity iron ion binding protein binding steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen lyase activity heme binding metal ion binding testosterone 6-beta-hydroxylase activity estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity hydroperoxy icosatetraenoate dehydratase activity aromatase activity oxidoreductase oxygenase metabolite interconversion enzyme
Process(es)
angiogenesis trabecular meshwork development lipid metabolic process fatty acid metabolic process steroid catabolic process xenobiotic metabolic process nitric oxide biosynthetic process cell adhesion steroid metabolic process estrogen metabolic process negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress toxin metabolic process response to toxic substance positive regulation of vascular endothelial growth factor production sterol metabolic process arachidonic acid metabolic process epoxygenase P450 pathway collagen fibril organization negative regulation of cell migration negative regulation of NF-kappaB transcription factor activity negative regulation of cell adhesion mediated by integrin xenobiotic catabolic process hormone metabolic process benzene-containing compound metabolic process retinol metabolic process retinal metabolic process positive regulation of apoptotic process blood vessel endothelial cell migration endothelial cell migration positive regulation of angiogenesis positive regulation of JAK-STAT cascade membrane lipid catabolic process blood vessel morphogenesis retina vasculature development in camera-type eye retinal blood vessel morphogenesis cellular response to hydrogen peroxide endothelial cell-cell adhesion omega-hydroxylase P450 pathway olefinic compound metabolic process regulation of reactive oxygen species metabolic process DNA modification cellular aromatic compound metabolic process response to nutrient male gonad development response to organic substance response to organic cyclic compound positive regulation of smooth muscle cell migration dibenzo-p-dioxin metabolic process adrenal gland development response to follicle-stimulating hormone response to estradiol estrous cycle positive regulation of translation response to arsenic-containing substance response to steroid hormone oxidation-reduction process ganglion development cellular response to cAMP cellular response to tumor necrosis factor cellular response to luteinizing hormone stimulus cellular response to cortisol stimulus cellular response to progesterone stimulus cellular response to organic cyclic compound response to dexamethasone response to indole-3-methanol positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process
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