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Invitrogen
EpoR Polyclonal Antibody
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Product Details
PA5-91874
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 274-508 of human EPOR (NP_0001121)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Amount
54 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: K-562, Mouse kidney, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein
Immunogen sequence: HRRALKQKIW PGIPSPESEF EGLFTTHKGN FQLWLYQNDG CLWWSPCTPF TEDPPASLEV LSERCWGTMQ AVEPGTDDEG PLLEPVGSEH AQDTYLVLDK WLLPRNPPSE DLPGPGGSVD IVAMDEGSEA SSCSSALASK PSPEGASAAS FEYTILDPSS QLLRPWTLCP ELPPTPPHLK YLYLVVSDSG ISTDYSSGDS QGAQGGLSDG PYSNPYENSL IPAAEPLPPS YVACS
Target Information
EpoR encodes the erythropoietin receptor, which belongs to the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which in turn activates various intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. The stimulated erythropoietin receptor plays a role in the survival of erythroid cells. Defects in this gene may result in erythroleukemia and familial erythrocytosis. Dysregulation of this gene may also affect the growth of certain tumors. Multiple transcript variants are produced as a result of alternate splicing. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EPO R; EPO-R; Erythropoietin receptor; erythropoietin receptor precursor; pEpoR; unnamed protein product
Gene Aliases: EPO-R; EPOR
UniProt ID: (Human) P19235, (Mouse) P14753
Entrez Gene ID: (Human) 2057, (Mouse) 13857, (Rat) 24336
signal transduction
brain development
heart development
erythropoietin-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
decidualization
heart morphogenesis
positive regulation of cytosolic calcium ion concentration
embryo development
viral process
negative regulation of neuron apoptotic process
cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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