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Invitrogen
EED Polyclonal Antibody
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Product Details
PA5-92427
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-400 of human EED (NP_6945361)
Conjugate
Form
Liquid
Concentration
1.98 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK
Positive Samples: Mouse heart; Cellular Location: Chromosome, Nucleus
Target Information
The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1), also called embryonic ectoderm development, is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones, which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin Beta-7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EED; polycomb group protein; Embryonic ectoderm development protein; Heed; lethal, Chr 7, Rinchik 5; Polycomb protein EED; polycomb-group protein; similar to Mus musculus Eed; unnamed protein product; WAIT-1; WD protein associating with integrin cytoplasmic tails 1
Gene Aliases: COGIS; EED; ENSMUSG00000039373; HEED; l(7)5Rn; l7Rn5; lusk; WAIT1
UniProt ID: (Human) O75530, (Mouse) Q921E6
Entrez Gene ID: (Human) 8726, (Mouse) 13626, (Rat) 293104
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
spinal cord development
heterochromatin assembly
negative regulation of transcription, DNA-templated
oligodendrocyte differentiation
genetic imprinting
facultative heterochromatin formation
cellular response to leukemia inhibitory factor
regulation of adaxial/abaxial pattern formation
regulation of gene expression by genetic imprinting
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone methylation
positive regulation of histone H3-K27 methylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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