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Invitrogen
DYRK1A Polyclonal Antibody
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FIGURE: 1 / 5
DYRK1A Antibody (PA5-95499) in ICC/IF
Immunofluorescence analysis of DYRK1A in U20S cell. Antigen retrieval was performed on the tissue using IHC enzyme antigen retrieval reagent and blocked with 10% goat serum. Samples were incubated with DYRK1A polyclonal antibody (Product # PA5-95499) at a 2 µg/mL dilution, followed by Cy3 conjugated Goat anti-rabbit IgG using a 1:100 dilution and DAPI.
Product Details
PA5-95499
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human DYRK1A recombinant protein (Position: H38-M269).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, rat skeletal muscle tissue. ICC/IF: U2OS cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; OTTHUMP00000109090; Protein kinase minibrain homolog; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase; unnamed protein product
Gene Aliases: DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH; MRD7; PSK47
UniProt ID: (Human) Q13627, (Rat) Q63470
Entrez Gene ID: (Human) 1859, (Rat) 25255
nucleotide binding
transcription coactivator activity
actin binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
cytoskeletal protein binding
RNA polymerase II carboxy-terminal domain kinase activity
tubulin binding
kinase activity
transferase activity
identical protein binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
histone H3T45 kinase activity
splicing factor binding
protein self-association
regulation of alternative mRNA splicing, via spliceosome
protein phosphorylation
nervous system development
circadian rhythm
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
regulation of endocytosis
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
negative regulation of microtubule polymerization
negative regulation of heterochromatin assembly
positive regulation of RNA splicing
positive regulation of transcription, DNA-templated
regulation of beta-amyloid formation
regulation of neurofibrillary tangle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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