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Invitrogen

Lactoferrin Polyclonal Antibody

1 Published Figure
2 References
View all (63) Lactoferrin antibodies

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Lactoferrin Polyclonal Antibody

Product Details

PA5-95513

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human Lactoferrin recombinant protein (Position: D529-K710).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807315

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human liver tissue. IHC: human intestinal cancer tissue, human lung cancer tissue, mouse spleen tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; HLF; HLF2; iron binding protein; transferrin family member; iron transfer protein; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; minisatellite 10r detected by probe MMS10; N lobe; neutrophil lactoferrin; Talalactoferrin; unnamed protein product

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Gene Aliases: Csp82; GIG12; HEL110; HLF2; LF; LTF; MMS10R; Ms10r

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UniProt ID: (Human) P02788, (Mouse) P08071

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Entrez Gene ID: (Human) 4057, (Mouse) 17002, (Rat) 301034

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Function(s)
lipopolysaccharide binding DNA binding serine-type endopeptidase activity cysteine-type endopeptidase inhibitor activity iron ion binding protein binding heparin binding peptidase activity serine-type peptidase activity hydrolase activity protein serine/threonine kinase activator activity metal ion binding membrane destabilizing activity molecular_function ferric iron binding transfer/carrier protein
Process(es)
ossification regulation of cytokine production innate immune response in mucosa immune system process proteolysis ion transport iron ion transport humoral immune response antibacterial humoral response antifungal humoral response killing of cells of other organism negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway defense response to bacterium negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral process negative regulation of viral genome replication innate immune response positive regulation of osteoblast differentiation negative regulation of membrane potential negative regulation of viral process defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity cytolysis by host of symbiont cells bone morphogenesis antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of protein serine/threonine kinase activity positive regulation of bone mineralization involved in bone maturation negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development transport iron ion homeostasis retina homeostasis cellular iron ion homeostasis biological_process
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