Search

  • Order Status
  • Quick Order

Invitrogen

ACVR2A Polyclonal Antibody

View all (20) ACVR2A antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-96020

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.03 mg/mL

Amount

203 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807822

Product Specific Information

Positive Samples: SW480, Mouse kidney, Rat testis, Rat ovary; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: activin A receptor, type IIA; activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; type II activin receptor; unnamed protein product

View more View less

Gene Aliases: ACTRII; ActrIIa; ACVR2; ACVR2A; rActR-II; TactrII

View more View less

UniProt ID: (Human) P27037, (Rat) P38444, (Mouse) P27038

View more View less

Entrez Gene ID: (Human) 92, (Rat) 29263, (Mouse) 11480

View more View less

Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein binding ATP binding coreceptor activity kinase activity activin receptor activity, type I activin receptor activity, type II transferase activity activin-activated receptor activity growth factor binding PDZ domain binding inhibin binding identical protein binding metal ion binding activin binding BMP receptor activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity protein self-association transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
osteoblast differentiation gastrulation with mouth forming second positive regulation of protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis determination of left/right symmetry pattern specification process mesoderm development male gonad development anterior/posterior pattern specification regulation of signal transduction negative regulation of ossification positive regulation of bone mineralization BMP signaling pathway developmental process activin receptor signaling pathway positive regulation of activin receptor signaling pathway odontogenesis of dentin-containing tooth sperm ejaculation penile erection regulation of nitric oxide biosynthetic process positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system development Sertoli cell proliferation positive regulation of SMAD protein import into nucleus cellular response to growth factor stimulus cellular response to BMP stimulus protein phosphorylation response to organic substance positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation regulation of BMP signaling pathway positive regulation of follicle-stimulating hormone secretion regulation of nitric-oxide synthase activity phosphorylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support