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Invitrogen

PPAR delta Polyclonal Antibody

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PPAR delta Polyclonal Antibody

Product Details

PA5-96377

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 102-361 of human PPARD (NP_8031841)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.26 mg/mL

Amount

126 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808179

Product Specific Information

Positive Samples: BT-474, Mouse heart; Cellular Location: Nucleus

Immunogen sequence: IRMKLEYEKC ERSCKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ANEGSQYNPQ VADLKAFSKH IYNAYLKNFN MTKKKARSIL TGKASHTAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYKEI SVHVFYRCQC TTVETVRELT EFAKSIPSFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD GLLVANGSGF VTREFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGGE

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; nuclear receptor; PPARdelta; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARD/MYO1D fusion; PPARdelta/beta; unnamed protein product

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Gene Aliases: FAAR; NR1C2; NUC-1; NUC1; NUCI; NUCII; PPAR-beta; PPAR-delta; PPAR[b]; PPARB; Pparb/d; PPARD; PPARdelta

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UniProt ID: (Human) Q03181, (Mouse) P35396

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Entrez Gene ID: (Human) 5467, (Rat) 25682, (Mouse) 19015

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding fatty acid binding protein binding zinc ion binding lipid binding sequence-specific DNA binding metal ion binding NF-kappaB binding linoleic acid binding sequence-specific double-stranded DNA binding transcription coactivator activity drug binding protein heterodimerization activity enzyme activator activity prostacyclin receptor activity retinoid X receptor binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter placenta development glucose metabolic process proteoglycan metabolic process generation of precursor metabolites and energy regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation apoptotic process heart development embryo implantation cholesterol metabolic process cell proliferation axon ensheathment phospholipid biosynthetic process fatty acid catabolic process response to glucose hormone-mediated signaling pathway positive regulation of gene expression negative regulation of cholesterol storage response to activity regulation of skeletal muscle satellite cell proliferation negative regulation of smooth muscle cell migration fatty acid transport fatty acid oxidation cell differentiation negative regulation of cell growth intracellular steroid hormone receptor signaling pathway intracellular receptor signaling pathway cell-substrate adhesion cellular response to nutrient levels negative regulation of collagen biosynthetic process response to vitamin A positive regulation of insulin secretion involved in cellular response to glucose stimulus wound healing regulation of cell proliferation vasodilation negative regulation of apoptotic process positive regulation of skeletal muscle tissue regeneration protein kinase B signaling keratinocyte proliferation regulation of fat cell differentiation positive regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermis development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation decidualization negative regulation of smooth muscle cell proliferation epithelial cell proliferation regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response keratinocyte migration positive regulation of protein kinase B signaling adipose tissue development fat cell proliferation positive regulation of fat cell proliferation cellular response to lipopolysaccharide cellular response to hypoxia energy homeostasis apoptotic signaling pathway negative regulation of pri-miRNA transcription from RNA polymerase II promoter glucose transmembrane transport positive regulation of myoblast proliferation vitamin A metabolic process positive regulation of cell proliferation mRNA transcription response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of insulin secretion steroid hormone mediated signaling pathway positive regulation of vasodilation transcription, DNA-templated transcription from RNA polymerase II promoter G-protein coupled receptor signaling pathway epidermis development cellular process anagen positive regulation of catalytic activity regulation of insulin secretion
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