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Invitrogen
ING1 Polyclonal Antibody
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FIGURE: 1 / 1
ING1 Antibody (PA5-96854) in WB
Western blot analysis of ING1 in extracts of various cell lines. Samples were incubated with ING1 Polyclonal antibody (Product # PA5-96854) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-96854
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide of human ING1.
Conjugate
Form
Liquid
Concentration
6.15 mg/mL
Amount
615 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: SKOV3, HT-29, NIH/3T3, Mouse testis, Mouse brain, Mouse spleen, Mouse lung, Rat brain, Rat liver; Cellular Location: Nucleus
Target Information
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: growth inhibitor ING1; growth inhibitor; tumor suppressor candidate; growth inhibitory protein ING1; Inhibitor of growth protein 1; p33ING; p33ING1; tumor suppressor ING1; unnamed protein product
Gene Aliases: 2610028J21Rik; AA407184; AI875420; ING1; mING1h; p24ING1c; p33; p33ING1; p33ING1b; p33ING1c; p37Ing1b; p47; p47ING1a
UniProt ID: (Human) Q9UK53, (Mouse) Q9QXV3
Entrez Gene ID: (Human) 3621, (Rat) 306626, (Mouse) 26356
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
protein import into nucleus
negative regulation of cell proliferation
negative regulation of cell growth
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of programmed cell death
positive regulation of transcription, DNA-templated
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
biological_process
regulation of cell death
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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