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Invitrogen
RAB23 Polyclonal Antibody
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FIGURE: 1 / 1
RAB23 Antibody (PA5-96885) in WB
Western blot analysis of RAB23 in extracts of various cell lines. Samples were incubated with RAB23 Polyclonal antibody (Product # PA5-96885) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96885
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RAB23 (NP_0573613)
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Amount
82 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV SSWREKVVAE VGDIPTVLVQ NKIDLLDDSC IKNEEAEALA KRLKLRFYRT SVKEDLNVNE VFKYLAEKYL QKLKQQIAED PELTHSSSNK IGVFNTSGGS HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSCSIP; Positive Samples: HeLa, Mouse testis, Mouse brain, Mouse kidney, Mouse lung, Rat brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endosome membrane, Lipid-anchor, autophagosome, phagosome, phagosome membrane
Target Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781H0695; MGC8900; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; RAB family small GTP binding protein RAB 23; rab-15; Ras-related protein Rab-23; RP3-496N17.3; unnamed protein product
Gene Aliases: AW545388; HSPC137; opb; opb2; RAB23
UniProt ID: (Human) Q9ULC3
Entrez Gene ID: (Human) 51715, (Mouse) 19335, (Rat) 367242
autophagosome assembly
intracellular protein transport
cellular defense response
anatomical structure morphogenesis
protein transport
negative regulation of protein import into nucleus
GTP metabolic process
system development
cilium morphogenesis
craniofacial suture morphogenesis
neural tube closure
transport
signal transduction
small GTPase mediated signal transduction
multicellular organism development
nervous system development
regulation of smoothened signaling pathway
spinal cord dorsal/ventral patterning
dorsal/ventral neural tube patterning
Rab protein signal transduction
cilium assembly
embryonic digit morphogenesis
negative regulation of transcription factor import into nucleus
negative regulation of proteolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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