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Invitrogen
MC1R Polyclonal Antibody
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FIGURE: 1 / 6
MC1R Antibody (PA5-97961) in ICC/IF
Immunofluorescent analysis of MC1R in Hela cells using a MC1R polyclonal antibody (Product # PA5-97961) at a dilution of 1:133. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Product Details
PA5-97961
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Melanocyte-stimulating hormone receptor protein (1-37AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha melanocyte stimulating hormone receptor; MC1 receptor; MC1-R; Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; unnamed protein product
Gene Aliases: CMM5; MC1R; MSH-R; MSHR; SHEP2
UniProt ID: (Human) Q01726
Entrez Gene ID: (Human) 4157
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
UV protection
regulation of gene expression
sensory perception of pain
negative regulation of tumor necrosis factor production
intracellular signal transduction
melanin biosynthetic process
pigmentation
positive regulation of transcription from RNA polymerase II promoter
regulation of feeding behavior
UV-damage excision repair
positive regulation of cAMP/PKA signal transduction
positive regulation of feeding behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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