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Invitrogen
ENO1 Polyclonal Antibody
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Product Details
PA5-98203
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Alpha-enolase protein (2-428AA)
Conjugate
Form
Liquid
Concentration
2.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits, alpha, beta and gamma. Non Neuronal Enolase(ENO1) is an isoform of mammalian enolase and is composed of 2 alpha subunits. The gene for ENO1 also encodes a shorter monomeric structural lens protein, tau-crystallin. Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-phospho-D-glycerate hydro-lyase; 2-phospho-D-glycerate hydrolase; alpha enolase (EC 4.2.1.11); alpha enolase like 1; Alpha-enolase; c-Myc promoter binding protein; C-myc promoter-binding protein; ENO1 intronic transcript 1; ENO1 intronic transcript 1 (non-protein coding); enoa; Enolase 1; enolase 1, (alpha); enolase-alpha; epididymis secretory protein Li 17; MBP-1; MPB-1; MYC promoter-binding protein 1; NNE; Non-neural enolase; Phosphopyruvate hydratase; Plasminogen-binding protein; tau-crystallin; transcription factor; unnamed protein product
Gene Aliases: 0610008I15; AL022784; Eno-1; ENO1; ENO1-IT1; ENO1L1; HEL-S-17; MBP-1; MBPB1; MPB1; NNE; PPH
UniProt ID: (Human) P06733, (Mouse) P17182
Entrez Gene ID: (Human) 2023, (Mouse) 13806
magnesium ion binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription corepressor activity
RNA binding
phosphopyruvate hydratase activity
protein binding
lyase activity
protein homodimerization activity
cadherin binding
metal ion binding
GTPase binding
poly(A) RNA binding
protein heterodimerization activity
lyase
negative regulation of transcription from RNA polymerase II promoter
gluconeogenesis
glycolytic process
response to virus
positive regulation of plasminogen activation
negative regulation of cell growth
negative regulation of transcription, DNA-templated
positive regulation of muscle contraction
canonical glycolysis
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
positive regulation of ATP biosynthetic process
in utero embryonic development
positive regulation of binding
cellular response to acid chemical
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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