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Invitrogen
HSPA1B Polyclonal Antibody
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FIGURE: 1 / 2
HSPA1B Antibody (PA5-98348) in ICC/IF
Immunofluorescent analysis of HSPA1B in PC-3 cells using a HSPA1B polyclonal antibody (Product # PA5-98348) at a dilution of 1:106. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Product Details
PA5-98348
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Heat shock 70 kDa protein 1B protein (418-641AA)
Conjugate
Form
Liquid
Concentration
0.98 mg/mL
Amount
98 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; Heat shock protein; Heat shock protein family A member 1A; Heat shock protein family A member 1B; HSP; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1/HSP70.2; HSP70I; unnamed protein product
Gene Aliases: HSP70-1; HSP70-1B; HSP70-2; HSP70.1; HSP70.2; HSP72; HSPA1; HSPA1A; HSPA1B; HSX70
UniProt ID: (Human) P0DMV8
Entrez Gene ID: (Human) 3304
nucleotide binding
virus receptor activity
G-protein coupled receptor binding
RNA binding
receptor binding
protein binding
ATP binding
ATPase activity
enzyme binding
heat shock protein binding
ubiquitin protein ligase binding
histone deacetylase binding
protein binding involved in protein folding
unfolded protein binding
C3HC4-type RING finger domain binding
ATP-dependent protein disaggregase activity
ATP-dependent protein folding chaperone
mRNA catabolic process
protein folding
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of cell growth
regulation of protein ubiquitination
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of interleukin-8 production
cellular response to oxidative stress
cellular response to heat
protein refolding
negative regulation of apoptotic process
positive regulation of erythrocyte differentiation
ATP metabolic process
viral entry into host cell
protein stabilization
positive regulation of NF-kappaB transcription factor activity
cellular heat acclimation
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to steroid hormone stimulus
positive regulation of microtubule nucleation
negative regulation of inclusion body assembly
regulation of mitotic spindle assembly
positive regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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