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Invitrogen

CD85j (ILT2) Polyclonal Antibody

1 Published Figure
1 Reference
View all (40) CD85j (ILT2) antibodies

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CD85j (ILT2) Polyclonal Antibody

Product Details

PA5-98738

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 1 protein (483-650AA)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2813351

Target Information

CD85j, also known as a member of the leukocyte immunoglobulin-like receptor (LIR) family, is a single transmembrane glycoprotein with a long cytoplasmic domain containing four immunoreceptor tyrosine-based inhibitory motifs (ITIMs). These motifs signal through interactions with SHP-1, transducing negative signals that inhibit immune response stimulation. CD85j is expressed on myeloid cells such as monocytes and dendritic cells, as well as on subsets of lymphoid cells including NK, T, and B cells. The expression of CD85j is correlated with leukemias such as acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). On CD8+ cells, CD85j expression is associated with effector cell function and plays a significant role in viral infections, including HIV, Epstein-Barr virus, and cytomegalovirus (CMV). CD85j binds to MHC class I molecules, including HLA-G, A, F, B27, E, and F, on antigen-presenting cells. The receptor helps control inflammatory responses and cytotoxicity, focusing the immune response and limiting autoreactivity. CD85j belongs to the subfamily B class of LIR receptors, which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and multiple transcript variants encoding different isoforms have been identified for this gene. Its gene is located in a cluster at chromosomal region 19q13.4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD85 antigen-like family member J; CD85j; Ig-like transcript 2; ILT-2; ILT2a; allelic form of ILT2; ILT2b; alternatively spliced form of ILT2; ILT2c; alternatively spliced form of ILT2; immunoglobulin heavy chain variable region; Immunoglobulin-like transcript 2; leucocyte Ig-like receptor B1; Leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor subfamily B member 3-like; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LIR-1; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7; unnamed protein product

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Gene Aliases: CD85J; ILT-2; ILT2; LILRB1; LIR-1; LIR1; MIR-7; MIR7; PIR-B; PIRB

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UniProt ID: (Human) Q8NHL6

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Entrez Gene ID: (Human) 10859, (Rat) 100912456

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Function(s)
beta-amyloid binding protein binding protein phosphatase 1 binding MHC class Ib protein complex binding MHC class Ib protein binding HLA-A specific inhibitory MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class I receptor activity MHC class Ib receptor activity inhibitory MHC class I receptor activity SH2 domain binding MHC class I protein binding protein homodimerization activity immunoglobulin receptor superfamily
Process(es)
negative regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host adaptive immune response T cell proliferation involved in immune response immune system process negative regulation of cytokine production involved in immune response immune response-regulating signaling pathway immune response-inhibiting cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway signal transduction cell surface receptor signaling pathway response to virus positive regulation of gene expression negative regulation of serotonin secretion receptor internalization negative regulation of interferon-beta production negative regulation of interferon-gamma production negative regulation of interleukin-10 production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production negative regulation of mononuclear cell proliferation negative regulation of T cell proliferation positive regulation of apoptotic process negative regulation of cell cycle negative regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter negative regulation of natural killer cell mediated cytotoxicity negative regulation of alpha-beta T cell activation defense response to virus negative regulation of calcium ion transport positive regulation of macrophage cytokine production cellular response to lipopolysaccharide negative regulation of transforming growth factor beta production dendritic cell differentiation interleukin-10-mediated signaling pathway negative regulation of dendritic cell apoptotic process negative regulation of CD8-positive, alpha-beta T cell activation negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of gamma-delta T cell activation involved in immune response negative regulation of dendritic cell differentiation negative regulation of osteoclast development negative regulation of cytokine secretion involved in immune response interferon-gamma production negative regulation of interferon-beta secretion negative regulation of tumor necrosis factor biosynthetic process negative regulation of interferon-gamma biosynthetic process positive regulation of cytolysis interferon-gamma secretion negative regulation of interleukin-10 secretion negative regulation of interleukin-12 secretion negative regulation of transforming growth factor-beta secretion
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