Search
Invitrogen
KV3.2 (KCNC2) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
KV3.2 (KCNC2) Antibody (PA5-99182) in ICC/IF
Immunofluorescent analysis of KV3.2 (KCNC2) in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and KV3.2 (KCNC2) polyclonal antibody (Product # PA5-99182) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fl... View More
Product Details
PA5-99182
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNC2(Accession Q96PR1), corresponding to amino acid residues G606-L638.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KCNC2.
Target Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels. The subunits vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits, which include the KV1, KV2, KV3, KV4 and KV9 proteins, as well as accessory subunits that modify the gating properties of the coexpressed KV subunits. KV3.2 is a multipass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. The tail of KV3.2 may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alternatively spliced variant; hKv3.2; Potassium channel voltage-gated Shaw-related subfamily C member 2; potassium channel, voltage gated Shaw related subfamily C, member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; Potassium voltage-gated channel subfamily C member 2; potassium voltage-gated channel, Shaw-related subfamily, member 2; Shaw-like potassium channel; unnamed protein product; Voltage-gated potassium channel KCNC2; Voltage-gated potassium channel Kv3.2; Voltage-gated potassium channel subunit Kv3.2
Gene Aliases: AW047325; B230117I07; DEE103; KCNC2; KShIIIA; KV3.2
UniProt ID: (Human) Q96PR1, (Rat) P22462, (Mouse) Q14B80
Entrez Gene ID: (Human) 3747, (Rat) 246153, (Mouse) 268345
ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
gated channel activity
ion channel binding
metal ion binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
protein binding
voltage-gated ion channel activity
voltage-gated ion channel
action potential
ion transport
potassium ion transport
response to toxic substance
response to light intensity
response to amine
optic nerve development
globus pallidus development
response to magnesium ion
ion transmembrane transport
nitric oxide-cGMP-mediated signaling pathway
response to ethanol
protein homooligomerization
protein heterooligomerization
transmembrane transport
membrane hyperpolarization
cellular response to ammonium ion
cellular response to nitric oxide
potassium ion transmembrane transport
cellular response to toxic substance
regulation of presynaptic membrane potential
regulation of action potential firing rate
positive regulation of potassium ion transmembrane transport
response to kainic acid
response to nerve growth factor
response to organic cyclic compound
transport
regulation of ion transmembrane transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support