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Invitrogen

Phospho-CtBP1 (Ser422) Polyclonal Antibody

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Phospho-CtBP1 (Ser422) Polyclonal Antibody

Product Details

PA5-99323

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CTBP1(Accession Q13363), corresponding to amino acid residues around phosphorylated Ser422.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818256

Product Specific Information

Antibody detects endogenous levels of CtBP1 only when phosphorylated at Sersine 422.

Target Information

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; BARS-50; brefeldin A-ADP-riboslyated substrate; brefeldin A-ribosylated substrate; C-terminal-binding protein 1; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; CtBP1; CtBP3; MGC104684; transcriptional repressor

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Gene Aliases: 50-kDaBFA-inducedADP-ribosylatedsubstrate; BARS; BARS-50; CTBP; CTBP1; CtBP1-L; CtBP1-S; Ctbp3; CtBP3/BARS; D4S115h; D5H4S115; D5H4S115E; HADDTS

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UniProt ID: (Human) Q13363, (Rat) Q9Z2F5, (Mouse) O88712

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Entrez Gene ID: (Human) 1487, (Rat) 29382, (Mouse) 13016

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Function(s)
transcription cofactor binding transcription corepressor binding chromatin binding transcription coactivator activity transcription corepressor activity protein binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein domain specific binding identical protein binding NAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding DNA-binding transcription factor binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding transcription factor binding transferase activity, transferring acyl groups protein homodimerization activity repressing transcription factor binding C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity gluconate dehydrogenase activity steroid dehydrogenase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity transcription cofactor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter protein phosphorylation Notch signaling pathway negative regulation of cell proliferation viral genome replication cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated synaptic vesicle endocytosis white fat cell differentiation regulation of cell cycle synaptic vesicle clustering transcription, DNA-templated positive regulation of histone deacetylation negative regulation of histone acetylation oxidation-reduction process membrane fusion negative regulation of histone H4 acetylation negative regulation of transcription from RNA polymerase II promoter by histone modification regulation of transcription, DNA-templated transcription from RNA polymerase II promoter metabolic process
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