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Invitrogen

Phospho-GATA1 (Ser142) Polyclonal Antibody

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Phospho-GATA1 (Ser142) Polyclonal Antibody

Product Details

PA5-99361

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human GATA1(Accession P15976), corresponding to amino acid residues around phosphorylated Ser142.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818294

Product Specific Information

Antibody detects endogenous levels of GATA1 only when phosphorylated at Serine 142.

Target Information

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Eryf1; erythroid DNA-binding protein; Erythroid transcription factor; erythroid transcription factor 1; GATA-1; GATA-binding factor 1; GATA-binding protein 1; GATA-binding protein 1 (globin transcription factor 1); GF-1; globin transcription factor 1; HGNC:4170; NF-E1 DNA-binding protein; nuclear factor, erythroid 1; transcription factor GATA1; unnamed protein product

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Gene Aliases: CNSHA9; ERYF1; GATA-1; GATA1; GF-1; GF1; HAEADA; NF-E1; NFE1; XLANP; XLTDA; XLTT

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UniProt ID: (Human) P15976, (Mouse) P17679, (Rat) P43429

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Entrez Gene ID: (Human) 2623, (Mouse) 14460, (Rat) 25172

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription cofactor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding chromatin DNA binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding C2H2 zinc finger domain binding sequence-specific double-stranded DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding DNA binding, bending DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of cytosolic calcium ion concentration cell-cell signaling cell proliferation negative regulation of cell proliferation male gonad development anatomical structure morphogenesis regulation of glycoprotein biosynthetic process regulation of definitive erythrocyte differentiation regulation of primitive erythrocyte differentiation myeloid cell differentiation cell differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation basophil differentiation eosinophil differentiation bone mineralization negative regulation of bone mineralization organ regeneration myeloid cell apoptotic process negative regulation of myeloid cell apoptotic process osteoblast proliferation positive regulation of osteoblast proliferation embryonic hemopoiesis eosinophil fate commitment negative regulation of apoptotic process positive regulation of mast cell degranulation cell fate commitment positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development system development erythrocyte development homeostasis of number of cells within a tissue Sertoli cell development primitive erythrocyte differentiation platelet aggregation cellular response to lipopolysaccharide cellular response to cAMP cellular response to follicle-stimulating hormone stimulus dendritic cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand transcription, DNA-templated positive regulation of peptidyl-tyrosine phosphorylation transcriptional activation by promoter-enhancer looping cellular response to thyroid hormone stimulus negative regulation of transcription regulatory region DNA binding
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