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Invitrogen

Phospho-p27 Kip1 (Thr198) Polyclonal Antibody

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Phospho-p27 Kip1 (Thr198) Polyclonal Antibody

Product Details

PA5-99375

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CDKN1B(Accession P46527), corresponding to amino acid residues around phosphorylated Thr198.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818308

Product Specific Information

Antibody detects endogenous levels of p27 Kip1 only when phosphorylated at Threonine 198.

Target Information

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDKN1B; CDN1B; Cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; P27 CDKN1B; p27(KIP1); p27Kip1; unnamed protein product

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Gene Aliases: CDKN1B; CDKN4; KIP1; MEN1B; MEN4; p27; P27KIP1

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UniProt ID: (Human) P46527

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Entrez Gene ID: (Human) 1027

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Function(s)
protein kinase inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding protein kinase binding protein phosphatase binding cyclin-dependent protein kinase activating kinase regulator activity cyclin binding ubiquitin protein ligase binding macromolecular complex binding chaperone binding binding, bridging molecular function inhibitor activity ubiquitin ligase activator activity
Process(es)
regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle placenta development potassium ion transport apoptotic process regulation of exit from mitosis Notch signaling pathway regulation of mitotic cell cycle heart development sensory perception of sound positive regulation of cell proliferation negative regulation of cell proliferation programmed cell death negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator regulation of cell migration positive regulation of microtubule polymerization negative regulation of kinase activity positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of DNA replication negative regulation of transcription, DNA-templated negative regulation of growth negative regulation of mitotic cell cycle autophagic cell death inner ear development negative regulation of epithelial cell proliferation nuclear export regulation of cell cycle epithelial cell proliferation involved in prostate gland development negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to antibiotic cellular response to lithium ion cellular senescence regulation of mitotic cell cycle phase transition regulation of lens fiber cell differentiation regulation of cell cycle G1/S phase transition epithelial cell apoptotic process negative regulation of cyclin-dependent protein kinase activity negative regulation of epithelial cell apoptotic process negative regulation of vascular smooth muscle cell proliferation negative regulation of cardiac muscle tissue regeneration regulation of G1/S transition of mitotic cell cycle
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