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Invitrogen
MGMT Polyclonal Antibody
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Product Details
PA5-99442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MGMT(Accession P16455), corresponding to amino acid residues M1-K36.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MGMT.
Target Information
O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase (EC 2.1.1.63); Methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O(6)-alkylguanine-DNA alkyltransferase; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguan; O-6-methylguanine-DNA-alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O6-methylguanine-DNA methyltranferase; O6-methylguanine-DNA methyltransferase; unnamed protein product
Gene Aliases: Agat; AGT; AI267024; MGMT
UniProt ID: (Human) P16455, (Rat) P24528, (Mouse) P26187
Entrez Gene ID: (Human) 4255, (Rat) 25332, (Mouse) 17314
DNA repair
DNA dealkylation involved in DNA repair
cellular response to DNA damage stimulus
methylation
negative regulation of apoptotic process
positive regulation of double-strand break repair
response to toxic substance
response to organic cyclic compound
cellular response to oxidative stress
response to drug
regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to ethanol
positive regulation of DNA repair
response to folic acid
negative regulation of cell death
mammary gland epithelial cell differentiation
cellular response to organic cyclic compound
cellular response to ionizing radiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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