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Invitrogen

Phospho-hnRNP K (Ser284) Polyclonal Antibody

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Phospho-hnRNP K (Ser284) Polyclonal Antibody

Product Details

PA5-99481

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HNRNPK(Accession P61978), corresponding to amino acid residues around phosphorylated Ser284.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818414

Product Specific Information

Antibody detects endogenous levels of hnRNP K only when phosphorylated at Ser284.

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; HNRPK; RP11-575L7.1; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP; unnamed protein product

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Gene Aliases: AUKS; CSBP; HNRNPK; HNRPK; KBBP; NOVA; TUNP

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UniProt ID: (Human) P61978, (Mouse) P61979

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Entrez Gene ID: (Human) 3190, (Mouse) 15387

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Function(s)
nucleic acid binding DNA binding RNA binding mRNA binding protein binding protein domain specific binding identical protein binding cadherin binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter proximal region DNA binding single-stranded DNA binding mRNA 3'-UTR binding poly(A) RNA binding RNA metabolism protein
Process(es)
mRNA splicing, via spliceosome regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter RNA processing mRNA processing signal transduction RNA splicing negative regulation of gene expression chromatin silencing by small RNA regulation of apoptotic process negative regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of mRNA splicing, via spliceosome negative regulation of mRNA splicing, via spliceosome negative regulation of RNA metabolic process random inactivation of X chromosome regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of low-density lipoprotein particle clearance negative regulation of transcription from RNA polymerase II promoter ovarian follicle development transcription, DNA-templated transcription from RNA polymerase II promoter positive regulation of neuron projection development regulation of low-density lipoprotein particle clearance cellular response to insulin stimulus positive regulation of RNA splicing positive regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of receptor-mediated endocytosis positive regulation of synaptic transmission positive regulation of dendritic spine development cellular response to organic cyclic compound regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter positive regulation of synapse maturation positive regulation of long-term synaptic potentiation positive regulation of dendrite extension positive regulation of protein localization to cell surface negative regulation of branching morphogenesis of a nerve
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