Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

VDR Polyclonal Antibody

3 Published Figures
1 Reference
View all (25) VDR antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
VDR Polyclonal Antibody

Product Details

PA5-99506

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human VDR(Accession P11473), corresponding to amino acid residues S184-V234.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818439

Product Specific Information

Antibody detects endogenous levels of total Vitamin D Receptor.

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 1,25-dihydroxyvitamin D3 receptor; HGNC:12679; Nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; unnamed protein product; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D receptor; Vitamin D3 receptor

View more View less

Gene Aliases: NR1I1; PPP1R163; VDR

View more View less

UniProt ID: (Human) P11473, (Mouse) P48281

View more View less

Entrez Gene ID: (Human) 7421, (Mouse) 22337

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding vitamin D binding protein binding zinc ion binding lithocholic acid receptor activity sequence-specific DNA binding metal ion binding retinoid X receptor binding vitamin D response element binding calcitriol binding lithocholic acid binding calcitriol receptor activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis skeletal system development regulation of transcription, DNA-templated calcium ion transport cellular calcium ion homeostasis lactation negative regulation of cell proliferation organ morphogenesis positive regulation of gene expression negative regulation of keratinocyte proliferation cell differentiation positive regulation of bone mineralization intracellular steroid hormone receptor signaling pathway intracellular receptor signaling pathway phosphate ion transmembrane transport intracellular bile acid receptor signaling pathway mRNA transcription from RNA polymerase II promoter cell-cell junction maintenance positive regulation of keratinocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter decidualization retinoic acid receptor signaling pathway intestinal absorption apoptotic process involved in mammary gland involution positive regulation of apoptotic process involved in mammary gland involution mammary gland branching involved in pregnancy vitamin D receptor signaling pathway positive regulation of vitamin D receptor signaling pathway response to bile acid negative regulation of phosphate transmembrane transport transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development positive regulation of vitamin D 24-hydroxylase activity bile acid signaling pathway steroid hormone mediated signaling pathway regulation of calcium ion transport regulation of calcidiol 1-monooxygenase activity apoptotic signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support